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What is PAPP-A?
Pregnancy-associated plasma protein-A (PAPP-A) was first described in 1974 as a high molecular weight protein fraction in the serum of women in late pregnancy. It turned out that a large zinc-containing metalloglikoprotein with a molecular mass of about 800 kDa. During pregnancy, PAPP-A is produced by the trophoblast (fabric, which is the outer layer of the placenta) and extravillous cytotrophoblast (islet cells of the fetus in the thickness of the mucous layer of the uterus) and into the mother's bloodstream.
What is a subunit of free ?-HCG (human chorionic gonadotropin)?
Molecules of several pituitary hormones and the placenta hormones (thyroid-stimulating hormone (TSH), follicle-stimulating hormone (FSH), luteinizing hormone (LH) and human chorionic hormone (HCG)) have a similar structure and consist of ?-subunits.